Meet the Cambridge Scientist on Verge of Curing Multiple Sclerosis

Meet the Cambridge Scientist on Verge of Curing Multiple Sclerosis

Interesting new breakthrough in multiple sclerosis treatment. This one was new for me so I had to post it for my readers. It isn’t stem cells or B-cell blockers, it is about the cell that turns on in MS that attacks the body. It is about regeneration of damaged tissue. This is the kind of medicine that can help me one day and gives me hope.

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The Potential Cure

After discovering a small binary switch which regulates inside the immune cells. Su is now working with a stem-cell particle called LIF, which has the potential to control the cell and ensure it doesn’t attack healthy bodily tissues, while still protecting us and releasing an attack when needed. LIF stem-cell particles are a form of regenerative medicine, playing a role in tissue repair while keeping the brain and spinal cord healthy.

Su’s approach is what she calls a “double whammy”, she’s finding a way to reverse the autoimmunity, and also repair the damage caused in the brain.”

After celebrating her discovery, she hit a snag, she found that LIF could only survive for 20-minutes before being broken down by the body, meaning there would not be enough time for the therapeutic actions to deploy. This is where the technology of nanoparticles came in.

The Role of Nanoparticles

A combination of LIF and nanoparticles are compatible with the body, and they slowly dissolve like soluble stitches. The nanoparticles become the delivery device which administers the LIF over a period of five days.

As Su states “the nanoparticle itself is a protective environment, and the enzymes that break it down can’t access it. You can also decorate the surface of the particles with antibodies, so it becomes a homing device that can target specific parts of the brain. So you get the right dose, in the right place, and at the right time.”

The particles themselves were developed at Yale University, but LIFNano has the worldwide license to deploy them, and Su believes we are on the verge of some groundbreaking medicine.

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